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The efficacy of HITV Therapy is greater in the following patient'2 conditions:
- Solid Lump- applicable for any type of solid cancers at any stage as long as they are accessible by needle.However HIVT Therapy is not suitable for leukaemia and brain tumours.
- Tumours localised in treatble sites - as intra-tumoural injection of dendritic cells is the hallmark of HITV, it is important that the tumour is located in parts of the body that are accessble by needle.
- Tumour size of less than 3 cm in diameter- this limitation is due to the standard beam diameter of tomotherapy which is 3 cm. Dendritic cell viccine is also ineffective when injectedd into the necrotic(dead tissie) center of large tumours.
- Less than five metastatic tumour leasions- again, the limitation is due to the adverce reaction to rafiotheraoy that may occur when multiple sites have to be treated in one sittiing. However, Dr Hasumi has experience in treating up to 15 lesions in one go.
- No pleursl or peritioneal ascitic effusion-pleural and peritoneal ascitic effusion are typical sign of ectensive cancer dissemination and the chances of success in such cases is greatly diminished.
The protocol involves the harvesting of peripheral bood mononuclear cells from the patient and culturing them in the laboratory to differentiate into immature dendritic cells and then introducing them back into the patien's body through injections into tumour(s).In rouund 1, the cultured immature dendritic cells that have been injected into the tumour act as the reconnissance soldiers that will hunt out the cancer cell and gather information for the infantry. Once the information is passed on to the infantry, the soldiers or killer t-cells will launch specific attacks to distroy the enemies(cancer cell).
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